ACTA Pharmaceutica Sciencia 2020 , Vol 58 , Num 1
Development, Characterisation and Evaluation of PVP K-30/PEG Solid Dispersion Containing Ketoprofen
Meenakshi Bhatia 1 Sunita Devi 1
1 Guru Jambheshwar University of Science and Technology, Pharmaceutical Sciences, Hisar, India
DOI : 10.23893/1307-2080.APS.05806 The present study is designed with the objective to enhance the aqueous solubility of ketoprofen. For the said purpose solid dispersion employing PVP K-30 and PEG 6000 is prepared by hot melt method. The preparation of solid dispersion (SD) was optimized using 2-factor, 3 level central composite design. The preparation of SD was characterized by FTIR, DSC, XRD and SEM studies. Further, solubility, Gibb"s energy and in vitro release study was determined for different batches of the formulation as suggested by the design expert. The solubility of different batches of SD was found to be between 36.2 to 53.0µg/ml whereas pure drug and physical mixture possess the solubility of 14.4 and 23.8 µg/mL, respectively. The in vitro release is found to be 76.74 to 95.32% and PM shows 75.4 % release and pure drug shows 23.5 % release. Thus, the ketoprofen-loaded solid dispersion would be useful for delivering poorly water-soluble ketoprofen with enhanced dissolution, solubility and no crystalline changes. Keywords : Ketoprofen, solid dispersion, dissolution rate, solubility study

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