ACTA Pharmaceutica Sciencia 2019 , Vol 57 , Num 4
Investigation of the Anti-inflammatory and Hypoglycaemic Effects of Macaranga hurifolia Beille (Eurphorbiaceae) Extract on Wistar albino Rats
Peter Segun 1 Morenike Gbadebo 1 Modupe Adebowale 1 Katherine Olufolabo 1 Adediwura Fred-Jaiyesimi 1
1 Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu 8 Campus, Nigeria
DOI : 10.23893/1307-2080.APS.05726 Macaranga hurifolia Beille (Euphorbiaceae) is used in Nigerian ethnobotany for treating several diseases. This work was designed to determine the phytochemical composition, as well as, investigate the anti-inflammatory and hypoglycaemic activities of Macaranga hurifolia extract (MHE). MHE was evaluated for its anti- inflammatory and antidiabetic potentials using the egg albumin inflammatory model and alloxan-induced diabetic rat model, respectively. MHE produced both dose-dependent and time-dependent inhibition of oedema development with its maximum effect (69.6%) produced at the dose of 300 mg/kg. The acute in vivo antidiabetic study revealed that MHE produced significant hypoglycaemic effects at doses of 200 mg/kg (54% reduction) and 400 mg/kg (59% reduction), comparable to glibenclamide (5 mg/kg) which caused a 42% decrease, while all the treatment groups produced at least 25% reduction in blood glucose level for the chronic study. This study established, for the first time, the anti-inflammatory and antidiabetic potentials of Macaranga hurifolia. Keywords : Alloxan, diabetes mellitus, egg albumin, inflammation, Macaranga hurifolia

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