ACTA Pharmaceutica Sciencia 2019 , Vol 57 , Num 1
Antimicrobial Evaluation of Trisubstituted 2-piperazinyl Thiazoles
Betül Giray 1 Leyla Yurttaş 2 Zafer Şahin 3 Barkın Berk 3 Şeref Demirayak 3
1 Istanbul Medipol University, School of Medicine, Department of Pharmaceutical Microbiology, 34083 İstanbul, Turkey
2 Anadolu Üniversitesi, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 26470 Eskişehir, Turkey
3 Istanbul Medipol University, School of Pharmacy, Department of Pharmaceutical Chemistry, 34083 İstanbul, Turkey
DOI : 10.23893/1307-2080.APS.05707 Thiazole and basic nitrogen containing rings are important chemical moieties of antimicrobial drugs. In recent, third generation cephalosporins include thiazole ring system. In this study, we synthesized 33 piperazine thiazole derivatives which were thought to show antimicrobial activity. Synthesize were realized with good yield using the method which reports the anticholinesterase properties of these compounds. Similar compounds with the same scaffold (2, 4, 5 trisubstituted thiazoles) are investigated for antimicrobial activity. Compounds 23-27 exhibited MIC: 256 ?M against S. aureus ATCC 25923. Besides, 27-33 group showed MIC: 256 ?M against K. pneumoniae UC57 and B. cereus. It is remarkable that the compound 27 showed antimicrobial activity against 4 different microorganisms and 26 showed antimicrobial activity against L. monocytogenes by MIC: 32 ?M which is same as the standart chloramphenicol. Keywords : thiazole, piperazine, antimicrobial, trisubstituted thiazole, N-benzoylthioamide

Istanbul Medipol University