ACTA Pharmaceutica Sciencia 2018 , Vol 56 , Num 4
Maternal Monosodium Glutamate Intake Influences the Learning Ability of the Offspring of Sprague Dawley Rats
İlyas Ün 1 Nihal Büyükuslu 2
1 Karadeniz Technical University, Tonya Vocational School of Applied Sciences, Trabzon, Turkey
2 Istanbul Medipol University, School of Health Sciences, Department of Nutrition and Dietetics, Istanbul, Turkey
DOI : 10.23893/1307-2080.APS.05628 Objectives: Monosodium glutamate (MSG) is one of the most widely consumed food additives. We aimed to identify the effects of maternal MSG intake on offspring"s learning ability in rats.

Patients and Methods: Among thirty female rats, ten control rats were fed by standart diet. Twenty rats were applied 4 mg/g.body weight for 3 weeks and then divided into group I (exposed MSG during pregnancy and lactation) and group II (no MSG). Pups had no MSG at any stage. The adult rats and the pups were applied Barnes maze to test learning ability.

Results: Barnes maze test resulted that the learning ability for offspring of MSG treated mother rats decreased in the order of control > maternal MSG intake for 3 weeks before mating > additional maternal MSG intake during pregnancy and lactation.

Conclusion: In conclusion maternal MSG intake increased the duration of trial and the number of false trial of offspring in Sprague Dawley rats. Keywords : Monosodium Glutamate, Barnes Maze, Learning Ability, Memory, Sprague Dawley Rats

Istanbul Medipol University