ACTA Pharmaceutica Sciencia 2018 , Vol 56 , Num 4
Hypoglycemic Potential of Combined Ethanol Extracts of Gongronema latifolia and Vernonia amygdalina Leaf in Alloxan-induced Diabetic Albino Wistar Rats
Effiom Etim 1 Edidiong Udo Akaka 1
1 Obong University, Biochemistry, Etim Ekpo/Akwa Ibom State, Nigeria
DOI : 10.23893/1307-2080.APS.05624 The effect of Gongronema latifolia (GL) and Vernonia amygdalina (VA) leaf extracts on glucose level in alloxan-induced diabetic rats was studied. Sixty albino rats (170g-200g) were divided into twelve groups with five animals per group. Group 1 and 12 served as normal and diabetic controls respectively. Groups 2, 3 and 4 were normal rats and received 150mg/kg of GL, VA and combined 100mg/kg each of GL and VA respectively. Groups 5, 6 and 7 were treated as Groups 2, 3 and 4 respectively before diabetes induction. Groups 8, 9 and 10 were treated as Groups 2, 3 and 4 respectively while Group 11 was treated with insulin after diabetes induction. Extract administration lasted for 14 days. Glucose level was significantly (P < 0.01) lowered in normal and post-diabetic treated rats as well as Groups 5 and 6. Combine extract of Gongronema latifolia and Vernonia amygdalina have good glucose lowering potential. Keywords : Vernonia amygdalina, Gongronema latifolia, Diabetes, Blood Glucose, Insulin

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