ACTA Pharmaceutica Sciencia 2018 , Vol 56 , Num 4
An Efficient Approach to the Synthesis of Thymidine Derivatives Containing Various Acyl Groups: Characterization and Antibacterial Activities
Md Arifuzzaman 1 Md Mirajul Islam 1 Md Monjur Rahman 1 Mohammad Atiar Rahman 2 Sarkar M. A. Kawsar 1
1 Laboratory of Carbohydrate and Nucleoside Chemistry, Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong-4331, Bangladesh
2 Department of Biochemistry and Molecular Biology, Faculty of Biological Science, University of Chittagong, Chittagong-4331, Bangladesh
DOI : 10.23893/1307-2080.APS.05622 In search of new leads toward potent antibacterial agents; therefore, a series of thymidine analogues were synthesized by direct acylation method and furnished the 5´-O-acyl thymidine derivatives in good yield. A number of acyl derivatives were prepared in order to obtain a series of newer components for antibacterial screening experiments. The synthesized compounds were characterized by their FTIR, 1HNMR spectral data and elemental analysis. These thymidine derivatives were evaluated for in vitro antibacterial screening studies against a number of human pathogenic microorganisms by disc diffusion method. The study revealed that most of the tested chemicals exhibited moderate to good antibacterial activities. It was also observed that the test chemical 2-bromobenzoyl derivative 11 very significantly inhibited the growth of all Gram-positive and Gram-negative bacterial strains used. For comparative studies, antibacterial activity of standard antibiotics, Azithromycin was also carried out against these microorganisms. Hence, these thymidine derivatives can be used to discover antibacterial agents that may serve as leads in the development of new pharmaceuticals research activities. Keywords : Thymidine, synthesis, derivatives, 1H-NMR, antibacterial

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