ACTA Pharmaceutica Sciencia 2005 , Vol 47 , Num 1
STUDIES ON SUSTAINED RELEASE MATRIX SYSTEMS OF CHLORZOXAZONE
TAMER GÜNERİ, FİLİZ TANERİ, GÖKHAN ERTAN
University of Ege, Faculty of Pharmacy, Department of Pharmaceutical Technology, Bornova, İzmir In this study, the aim was to prepare matrix tablets of chlorzoxazone to achieve a sustained release profile suitable for peroral administration. Matrix tablets were prepared by means of wet granulation method using Eudragit(r) RS 100 as the polymer. The effect of formulation factors on drug dissolution and kinetics of drug release were investigated. Matrix tablets prepared from the granules in ratio of 1:0.5:0.8:0.46 (Chlorzoxazone:Eudragit(r) RS 100:Lactose:Primojel(r)) and with the particle size of 250 urn, revealed the best release behaviour. Micromeritic investigations were also carried out on chlorzoxazone powder and the granules of the tablets which showed the best release profile. These tablets showed non-Fickian behaviour according to the curve fitting analysis. This study claimed to formulate a delivery system that may optimize the drug release and reduce the side effects by the preparation of matrix tablet formulation ofchlorzoxazone. Keywords : CHLORZOXAZONE, EUDRAGIT(r) RS 100, MATRIX TABLET, DISSOLUTION KINETICS, DIFFUSIONAL BEHAVIOUR, MICROMERITICS

Istanbul Medipol University